Category Archives: Epigenetics

Changes in DNA methylation in hypertension

On 11 jan 2013 a new paper from PredSL PI Harold Snieder and collaborators was published in the journal PLOS ONE entitled “A Genome-Wide Methylation Study on Essential Hypertension in Young African American Males. After Snieder’s group published the first epigenome-wide association study (EWAS) of obesity in 2010 this is now also the very first study of its kind investigating hypertension. They conclude that identification of a difference in a blood leukocyte DNA methylation site between hypertensive cases and normotensive controls suggests that changes in DNA methylation may play an important role in the pathogenesis of hypertension. The age dependency of the effect further suggests complexity of epigenetic regulation in this age-related disease.

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Harold Snieder appointed visiting professor at Estonian Genome Center

Today, PredSL PI Harold Snieder was appointed as visiting professor for 5 years at the Estonian Genome Center, University of Tartu, Estonia. Snieder is very excited about this appointment. The Estonian Biobank study is very similar to the LifeLines Biobank Cohort Study in both goals and scope, so he expects many opportunities for closer collaboration. Together they are in an even better position to tackle scientific questions regarding effects of genes, environmental exposures and their interactions on complex traits and diseases.

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