On 11 jan 2013 a new paper from PredSL PI Harold Snieder and collaborators was published in the journal PLOS ONE entitled “A Genome-Wide Methylation Study on Essential Hypertension in Young African American Males. After Snieder’s group published the first epigenome-wide association study (EWAS) of obesity in 2010 this is now also the very first study of its kind investigating hypertension. They conclude that identification of a difference in a blood leukocyte DNA methylation site between hypertensive cases and normotensive controls suggests that changes in DNA methylation may play an important role in the pathogenesis of hypertension. The age dependency of the effect further suggests complexity of epigenetic regulation in this age-related disease.
Changes in DNA methylation in hypertension